Status : Verified
| Personal Name | Dela Cruz, Isaac Jerome C. |
|---|---|
| Resource Title | The influence of volume in a confined space on the nucleation of model molecular crystals |
| Date Issued | 28 June 2021 |
| Abstract | Crystallization in confinement is a promising approach to nanocrystal development with benefits on polymorph access and stabilization. This study demonstrated the effects of volume reduction on the nucleation of different molecular crystals to elucidate the use of confinement for crystallization. Analysis of the nucleation of model crystals in confinement showed that reduction of sample volume results in an exponential increase in induction times. Induction times approximately increased by a factor of 50-55 upon a 40-fold reduction in volume while also reducing the probability of nucleation itself. Furthermore, the study suggests that confinement puts constraints on molecular mobility and self-association for nucleating cluster formation. Confinement magnifies the effects of the other critical aspects of crystallization, including solvent effects, molecular crystal size, and confinement material. This suggests that while confinement is indeed an excellent approach to nanocrystal development and polymorph stabilization, factors like surface morphology and confinement shape must always be considered. Finally, this research suggests that nucleation behavior and nucleation pathways known in bulk processes were altered by the confinement. |
| Degree Course | PhD Chemical Engineering |
| Language | English |
| Keyword | Crystallization; Nucleation; Crystals; Polymorphism; Confinement |
| Material Type | Thesis/Dissertation |
Preliminary Pages
231.85 Kb
Category : F - Regular work, i.e., it has no patentable invention or creation, the author does not wish for personal publication, there is no confidential information.
Access Permission : Open Access