Status : Verified
| Personal Name | Balanay, Mac Jayvin S. |
|---|---|
| Resource Title | The NAC of the Study: Exploring Micromeritics through the Lens of Spherical Crystallization of N-Acetylcysteine |
| Date Issued | June 2024 |
| Abstract | N-acetyl-l -cysteine (NAC) is a widely used mucolytic and antioxidant agent with diverse therapeutic applications. However, due to its poor stability, NAC faces significant challenges in its tablet manufacturing. Spherical crystallization has emerged as a promising technique, transforming a crystalline pharmaceutical to a form suitable for direct tableting. This study aims to apply spherical crystallization to form spherical NAC with improved solid-state properties. A systematic solvent system screening was conducted wherein spherical NAC was successfully obtained via a quasi-emulsion solvent diffusion (QESD) technique with water as the solvent and ethyl acetate as the antisolvent. The spherical crystals presented a hollow structure correlating to the QESD technique, with sphericity and roundness of 0.98 and 0.88, respectively. Spherical NAC bulk properties showed significant improvements in flowability and compressibility. Lastly, exploratory investigation on QESD showed that the addition of Tween 80 as a surfactant significantly affected particle morphology. Overall, the findings suggest that spherical crystallization is a useful technique for enhancing the flowability of NAC |
| Degree Course | Master of Science in Chemical Engineering |
| Language | English |
| Keyword | spherical crystallization; QESD; N-acetylcysteine; agglomeration; compressibility |
| Material Type | Thesis/Dissertation |
Preliminary Pages
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Category : P - Author wishes to publish the work personally.
Access Permission : Limited Access