Status : Verified
| Personal Name | Nabor, Angelo Rafael P. |
|---|---|
| Resource Title | In silico screening of potential bioactive peptides from selected coconut storage proteins in copra meal |
| Date Issued | 28 May 2025 |
| Abstract | The identification and extraction of bioactive peptides from plant sources is a growing research field due to their potential applications in functional foods and nutraceuticals. Bioinformatics tools offer a cost-effective, efficient, and time-saving approach for predicting protein bioactivities and optimizing experimental procedures, such as enzyme selection for producing copra meal hydrolysates (CMHs). This study utilized the in silico tool BIOPEP-UWM to assess the potential of thirteen representative copra meal (Cocos nucifera byproduct) proteins to generate bioactive peptides through hydrolysis with twelve proteases and two enzyme combinations. The findings indicate that copra meal is a promising source of antioxidant and angiotensin-converting enzyme (ACE) inhibitory peptides. Pepsin (pH > 2), thermolysin, and chymotrypsin C were the most effective at generating ACE inhibitory peptides, while stem bromelain was the most efficient at releasing antioxidant peptides. Additionally, combinations of gastrointestinal (GI) enzymes proved effective in producing significant amounts of both ACE inhibitors and antioxidants. However, no novel tripeptides were identified from the virtual hydrolysis. These results suggest that C. nucifera meal proteins are a valuable source of bioactive peptides with ACE inhibitory and antioxidant properties and that in silico approaches can provide a theoretical foundation for future in vitro and in vivo research on bioactive peptides derived from copra meal hydrolysates. |
| Degree Course | Bachelor of Science in Food Technology |
| Language | English |
| Keyword | In silico; Copra meal; Bioactive peptides; Coconut--Philippines; Plant proteins; Bioinformatics |
| Material Type | Thesis/Dissertation |
Preliminary Pages
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Category : F - Regular work, i.e., it has no patentable invention or creation, the author does not wish for personal publication, there is no confidential information.
Access Permission : Open Access